Endocannabinoid System

What is it?

Discovered in the 20th Century, the endocannabinoid system is a biological system composed of endocannabinoids that are neurotransmitters that bind to cannabinoid receptors in the mammalian brain and body. CBD is one of the primary cannabinoids found in hemp.

Endocannabinoids (and plant-based cannabinoids) link with protein molecule receptors on the surface of cells. CBD has also been shown to strengthen and improve the efficiency of mitochondria, the “powerhouses” of your cells that are responsible for ensuring that your cells work the way they should. Research on the ECS has shown that as part of regulating homeostasis, and is responsible for repairing damaged cells. Research has also shown that cannabinoids are able to target damaged cells while sparing normal cells, meaning that the Endocannabinoid system may act as a biological defense system.

When a person ingests Hemp CBD Oil or other cannabinoids, these cannabinoid receptors are activated (CBD appears to have a greater affinity for CB2 receptors than CB1 receptors). Research indicates that when you supplement your ECS with non-toxic, non-habit-forming cannabinoids, you may create a healthier endocannabinoid system and, almost certainly, a healthier you.

Concentrations

CBD
Receptors

Select and see

CB1 Receptors
1

Brain / CNS / Spinal Cord Cortigal Regions / Cerebellum / Brainstem (neocortex, pyriform cortex, hippocampus, amygdala)

2

Thyroid endocrine gland

3

Upper Airways of mammals

4

Liver kupffer cells (macrophage immune cells), hepatocytes (liver cell), hepatic stellate cells (fat storage cell)

5

Adrenals / Basal Ganglia / Thalamus / Pituitary / Hypothalamus / Olfactory Bulb endocrine gland / Globus pallidus, substantia nigra pars, reticulata / (endocrine-brain link CB1)

6

Ovaries gonads and endocrine gland

7

Uterus myometrium

8

Prostate epithelial and smooth muscle cells

9

Testes gonads and endocrine gland CB1): Leydig cells; sperm cells

CB2 Receptors
1

Eye Retinal pigment epithelial / RPE cells

2

Stomach

3

Heart

4

Pancreas

5

Digestive Tract

6

Bone

Brain Receptors
1

Basal Ganglia Movement

2

Cerebral Cortex Higher Cognitive Function

3

Hypothalamus Appetite

4

Cerebellum Movement

5

Hippocampus Learning, Memory, Stress

6

Medulla Nausea and vomiting, chemoreceptor

7

Spinal Cord Peripheral Sensation including Pain

CB1 Receptors
CB2 Receptors
Brain

How do these

Receptors
Work?

Cannabinoids help coordinate and regulate how we feel and think by binding with the endocannabinoid system’s CB1 and CB2 receptors. Fitting like puzzle pieces, cannabinoids are designed to link together with the cannabinoid receptors.

Linking activates the receiving neuron into action, triggering a set of events to pass along the message and carry out a variety of cellular responses needed for homeostasis and healthy functioning.